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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
JAK2
All Species:
33.94
Human Site:
S591
Identified Species:
82.96
UniProt:
O60674
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O60674
NP_004963.1
1132
130674
S591
D
K
A
H
R
N
Y
S
E
S
F
F
E
A
A
Chimpanzee
Pan troglodytes
XP_001139368
1132
130637
S591
D
K
A
H
R
N
Y
S
E
S
F
F
E
A
A
Rhesus Macaque
Macaca mulatta
XP_001082883
1132
130701
S591
D
K
A
H
R
N
Y
S
E
S
F
F
E
A
A
Dog
Lupus familis
XP_541301
1132
131117
S591
D
K
A
H
R
N
Y
S
E
S
F
F
E
A
A
Cat
Felis silvestris
Mouse
Mus musculus
Q62120
1129
130217
S591
D
K
A
H
R
N
Y
S
E
S
F
F
E
A
A
Rat
Rattus norvegicus
Q62689
1132
130567
S591
D
K
A
H
R
N
Y
S
E
S
F
F
E
A
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505937
950
110363
L509
G
L
H
Q
T
E
V
L
L
K
V
L
D
K
A
Chicken
Gallus gallus
Q75R65
1129
129828
S588
D
K
V
H
R
N
Y
S
E
S
F
F
E
A
A
Frog
Xenopus laevis
NP_001085288
1129
130564
S589
D
K
T
H
R
S
F
S
E
S
F
F
E
A
A
Zebra Danio
Brachydanio rerio
O12990
1153
132463
S631
G
S
G
H
R
D
I
S
L
A
F
F
E
T
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
99.2
94.5
N.A.
93.4
94.6
N.A.
78
87
77.6
42
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.7
99.7
97.5
N.A.
97.4
97.3
N.A.
81.3
93.3
89.1
60.7
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
6.6
93.3
80
46.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
13.3
93.3
93.3
60
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
60
0
0
0
0
0
0
10
0
0
0
80
100
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
80
0
0
0
0
10
0
0
0
0
0
0
10
0
0
% D
% Glu:
0
0
0
0
0
10
0
0
80
0
0
0
90
0
0
% E
% Phe:
0
0
0
0
0
0
10
0
0
0
90
90
0
0
0
% F
% Gly:
20
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
10
90
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% I
% Lys:
0
80
0
0
0
0
0
0
0
10
0
0
0
10
0
% K
% Leu:
0
10
0
0
0
0
0
10
20
0
0
10
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
70
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
90
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
10
0
0
0
10
0
90
0
80
0
0
0
0
0
% S
% Thr:
0
0
10
0
10
0
0
0
0
0
0
0
0
10
0
% T
% Val:
0
0
10
0
0
0
10
0
0
0
10
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
70
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _